Antiviral drugs specific for coronaviruses in preclinical development

Preclinical development of antiviral drugs.

The early preclinical development of an antiviral agent is accomplished essentially in two stages. The first stage consists of gathering data to estimate the potential therapeutic index of the agent. This process includes testing for antiviral activity and for cytotoxicity in vitro and performing preliminary pharmacokinetic and toxicology studies in vivo. The second stage consists of carrying o...

New preclinical strategies for characterization and development of anticancer drugs

Karlsson, H. 2017. New preclinical strategies for characterization and development of anticancer drugs. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1378. 59 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0101-3. Increased understanding of the molecular mechanisms underlying cancer development has shifted drug discovery towards target drive...

Preclinical Animal Models for the Development of Cancer Chemoprevention Drugs

Antiviral drugs for cytomegalovirus diseases.

Cytomegalovirus infections are associated with severe morbidity and mortality is patients at risk for disease because of immune system disabilities; in particular, recipients of stem cell (HSCT) or solid organ (SOT) transplants. There are three systemic drugs approved for CMV treatment: ganciclovir, or its prodrug valganciclovir, foscarnet, and cidofovir. An anti-sense therapeutic, ISIS 2922, i...

development and implementation of an optimized control strategy for induction machine in an electric vehicle

in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...